I did the initial design in sketchup. Then I redid the drawings in CorelDRAW since the laser cutter needs vector files. You can do it directly out of sketchup but I've found that you get really wonky cutting order because sketchup does screwy things with vectors. I think that whole process took two hours or so. I kept making mistakes with the measurements
The acrylic was just some 1/8 stock I had lying around. The laser cutter has good defaults for continuous cast acrylic so there was nothing special there. I want to say it was 2 minutes in the laser cutter.
I make my own acrylic glue. It's 10:1 Dicholomethane/Glacial Acetic Acid. Probably 30 minutes or so to glue it together.